Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.
نویسندگان
چکیده
Intimin-conjugated fluorescent beads bind to spleen CD4 T cells and Peyer's patch, mesenteric lymph node, and cecal follicle lymphocytes, with less binding to lamina propria T cells and intraepithelial lymphocytes. Intimin costimulates proliferation of spleen CD4 T cells and cells from organized lymphoid tissues but does not costimulate cells from the lamina propria of normal or inflamed colon.
منابع مشابه
Crystal Structure of EHEC Intimin: Insights into the Complementarity between EPEC and EHEC
Enterohaemorrhagic E. coli (EHEC) O157:H7 is a primary food-borne bacterial pathogen capable of causing life-threatening human infections which poses a serious challenge to public health worldwide. Intimin, the bacterial outer-membrane protein, plays a key role in the initiating process of EHEC infection. This activity is dependent upon translocation of the intimin receptor (Tir), the intimin b...
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Intimin is a bacterial outer membrane protein required for intimate attachment of enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) to mammalian cells. beta1-chain integrins have been proposed as candidate receptors for intimin. We found that binding of mammalian cells to immobilized intimin was not detectable unless mammalian cells were preinfected with EPEC or EHEC. beta...
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متن کاملAllele- and Tir-Independent Functions of Intimin in Diverse Animal Infection Models
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ورودعنوان ژورنال:
- Infection and immunity
دوره 71 5 شماره
صفحات -
تاریخ انتشار 2003